Literature references

References pertaining to infraluciferin:

Willey TL, Squirrell DJ and White PJ (2001). Design and selection of firefly luciferases with novel in vivo and in vitro properties. In Proc. 11th Int. Symp. Biolum. Chemilum. Editors: Case JF, Herring PJ, Robinson BH, Haddock SHD, Kricka LJ and Stanley PE. World Scientific, Singapore. Pgs 201-4.

Law GHE, Gandelman OA, Tisi LC, Lowe CR and Murray JAH (2006). Mutagenesis of solvent exposed amino acids in Photinus pyralis luciferase improves thermostability and pH-tolerance. Biochem. J. 397: 305-312.

Jathoul A, Law E, Gandelman O, Pule M, Tisi L and Murray J (2012a). Development of a pH tolerant thermostable Photinus pyralis luciferase for brighter in vivo imaging. In: Lapota D, editor. Bioluminescence - recent advances in oceanic measurements and laboratory applications. London: IntechOpen.

Jathoul AP, Philip B, Thomas S and Pule MA (2012b). Characterisation of a bright and thermostable rainbow of firefly luciferases: enhanced tools for in vivo bioluminescence imaging. World Molecular Imaging Conference poster session, 6th September 2012, Dublin, Ireland, UK. (( Nb. In this poster x11 green (x11 + V241I, G246A, F250S) and x11 red2 (x11 + S284T, R354I), or simply called x11 red in this poster, were first engineered and are called ‘FLuc_green’ and ‘FLuc_red’ in Stowe et al., 2019 (Elife 8: e45801). x11 red2 had proven very effective for NIR BLI with infraluciferin when tested in mouse models at UCL during 2013-2014 (unpublished).

Patent for infraluciferin held by Bioflares Ltd: Derivatives of luciferin (2014). EP 2981527 A1 (text from WO2014162157A1). Inventors: Amit P. JATHOUL, Helen GROUNDS, James C. Anderson, Martin A. PULE.

Jathoul AP, Grounds H, Anderson JC, Pule MA (2014). A dual-color far-red to near-infrared firefly luciferin analogue designed for multiparametric bioluminescence imaging. Angew. Chem. Int. Ed. Engl. 53: 13059-63.

Berraud-Pache R and Navizet I (2016). QM/MM calculations on a newly synthesised oxyluciferin substrate: new insights into the conformational effect. Phys. Chem. Chem. Phys. 18: 27460-7.

Anderson JC, Grounds H, Jathoul AP, Murray JAH, Pacman SJ and Tisi LC (2017). Convergent synthesis and optical properties of near-infrared emitting bioluminescent infra-luciferins. RSC Adv. 7: 3975-82.

Woodhouse JL, Assmann M, Parkes MA, Grounds H, Pacman SJ, Anderson JC, Worth GA and  Helen H. Fielding HH (2017). Photoelectron spectroscopy of isolated luciferin and infraluciferin anions in vacuo: competing photodetachment, photofragmentation and internal conversion. Phys. Chem. Chem. Phys. 19: 22711-20.

Halliwell LM, Jathoul AP, Bate JP, Worthy HL, Anderson JC, Jones DD and Murray JAH (2018).ΔFlucs: Brighter Photinus pyralis firefly luciferases identified by surveying consecutive single amino acid deletion mutations in a thermostable variant. Biotechnol. Bioeng. 115: 50-9.

Abdulla M, Jathoul A, Vinh N, et al (2018). I23 Tracking transplanted human foetal cells using bioluminescence imaging in a huntington’s disease model. Journal of Neurology, Neurosurgery & Psychiatry 2018;89:A96-A97.

Anderson JC, Chang CH, Jathoul AP and Syed AJ (2019). Synthesis and bioluminescence of electronically modified and rotationally restricted color-shifting infraluciferin analogues. Tetrahedron 75: 347-56.

Stowe C, Burley TA, Allan H, Vinci M, Kramer-Marek G, Ciobota DM, Parkinson GN, Southworth TL, Agliardi G, Hotblack A, Lythgoe MF, Branchini BR, Kalber TL, Anderson JC and Pule MA (2019). Near-infrared dual bioluminescence imaging in mouse models of cancer using infraluciferin. Elife 8: e45801.

Jathoul AP, Branchini BR, Anderson JC and Murray JAH (2022). A higher spectral range of beetle bioluminescence with infraluciferin. Front. Bioeng. Biotechnol. Sec. Biomaterials. Online: